Inqovi (decitabine and cedazuridine) is a medication used for the treatment of adults with myelodysplastic syndromes (MDS), including chronic myelomonocytic leukemia (CMML).
What is Inqovi (decitabine and cedazuridine) for?
Inqovi (decitabine and cedazuridine) is a medication used for the treatment of adults with myelodysplastic syndromes (MDS), including previously treated and untreated, de novo and secondary MDS with the following French-American-British subtypes (refractory anemia, refractory anemia with ringed sideroblasts, refractory anemia with excess blasts, and chronic myelomonocytic leukemia [CMML]) and intermediate-1, intermediate-2, and high-risk International Prognostic Scoring System groups.
It is available in vial form each containing 35 mg decitabine and 100 mg cedazuridine.
How does Inqovi (decitabine and cedazuridine) work?
In healthy cells, tumor suppressor genes slow down cell division and make sure growth and proliferation occurs normally. When the tumor suppressor gene function is disrupted, leading to uncontrolled growth and division, and ultimately to cancer.
Decitabine has two functions. It ‘hypomethylates’, switches off, tumor suppressor genes, causing restoration of their function, and thereby help them regain control over cell division.
Additionally, decitabine also functions as an antimetabolite. This means that it looks very similar to substances that are used by the cell for regular growth and division. When taken up by cells, these antimetabolites will have a cytotoxic effect, leading to death of rapidly dividing cells. Because normal cells do not proliferate often, they are relatively insensitive to decitabine’s effect.
Cedazuridine is a cytidine deaminase (CDA) inhibitor. CDA is a type of protein that breaks down substances, including decitabine, making them less available for the body to use. By administering decitabine together with cedazuridine, the efficiency of decitabine will be increased. Buy Now